Andrea Ilari Selected Research

trypanothione

2/2020	Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
11/2018	Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
1/2012	The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

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Andrea Ilari Research Topics

Disease

17	Neoplasms (Cancer) 02/2024 - 03/2010
11	Leishmaniasis 01/2024 - 04/2009
7	Infections 01/2022 - 01/2012
4	Huntington Disease (Huntington's Disease) 12/2021 - 01/2017
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 10/2020
2	Carcinoma (Carcinomatosis) 01/2021 - 01/2018
2	Trypanosomiasis 04/2020 - 01/2018
2	Arthritis (Polyarthritis) 02/2013 - 04/2012
1	Cardiotoxicity 10/2023
1	Central Nervous System Diseases (CNS Diseases) 03/2023
1	Parasitic Diseases (Parasitic Disease) 02/2023
1	Communicable Diseases (Infectious Diseases) 02/2023
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2017
1	Weight Loss (Weight Reduction) 01/2017
1	Neglected Diseases 01/2012

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 07/2023 - 04/2012
7	EnzymesIBA 12/2022 - 01/2015
6	trypanothione reductaseIBA 01/2024 - 01/2015
5	tryparedoxin peroxidaseIBA 02/2020 - 01/2012
4	CalciumIBA 07/2023 - 11/2015
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2020 - 01/2015
4	tryparedoxinIBA 02/2020 - 01/2012
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2023 - 01/2017
3	trypanothioneIBA 02/2020 - 01/2012
3	AntimonyIBA 01/2018 - 04/2009
3	Calcium-Binding ProteinsIBA 01/2017 - 09/2014
2	AnthracyclinesIBA 10/2023 - 01/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 01/2017
2	Adenosine Triphosphate (ATP)IBA 04/2020 - 01/2017
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 04/2020 - 01/2017
2	MetalsIBA 02/2013 - 04/2012
2	DNA (Deoxyribonucleic Acid)IBA 02/2013 - 04/2012
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 02/2024
1	ErbB Receptors (EGF Receptor)IBA 07/2023
1	Epidermal Growth Factor (EGF)IBA 07/2023
1	snake venom protein C activatorIBA 02/2023
1	Huntingtin ProteinIBA 12/2021
1	Sigma-1 ReceptorIBA 01/2021
1	taxaneIBA 01/2021
1	Antineoplastic Agents (Antineoplastics)IBA 01/2021
1	Taxoids (Taxanes)IBA 01/2021
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 04/2020
1	Sulfides (Thioethers)IBA 02/2020
1	Arsenicals (Arsenic Compounds)IBA 01/2018
1	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)IBA 01/2018
1	NucleotidesIBA 01/2018
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2018
1	ApoferritinsIBA 01/2018
1	Adenosine Diphosphate (ADP)IBA 01/2018
1	glycerate 1,3-biphosphateIBA 01/2018
1	Coordination ComplexesIBA 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Vinca AlkaloidsIBA 01/2017
1	PENTAIBA 11/2015
1	deoxyhypusine synthaseIBA 01/2015
1	trypanothione synthetaseIBA 01/2015
1	Spermidine SynthaseIBA 01/2015
1	deoxyhypusine hydroxylaseIBA 01/2015
1	ArginaseIBA 01/2015
1	Adenosylmethionine DecarboxylaseIBA 01/2015
1	PolyaminesIBA 01/2015
1	theasinensin AIBA 01/2015
1	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2015
1	Sulfhydryl Compounds (Thiols)IBA 01/2012
1	SilverIBA 03/2011

Therapy/Procedure

6	Therapeutics 10/2023 - 03/2010
1	Aftercare (After-Treatment) 10/2023